Faculty Profile


Name :

Dr. Romila Manchanda


Email :

romila.m@krmangalam.edu.in


Designation :

Associate Professor

Education

  • Ph.D. (Chemistry), 2007 from CCS Meerut, and IGIB, Mall road Delhi. (PhD thesis on               Design and synthesis of polymeric nanospheres as carrier for Biomolecules
  • MSC.  (chemistry), 1996-1998 from Delhi University
  • BSc. (Chemistry), 1992-1995 from Delhi University
Work Experience

  • 2003-2004:  Postdoc fellow at Univ. Pari-sud, Paris, France
  • 2007-2011:  Postdoc  Researcher  at FIU University, Miami, USA
  • 2011-2012:   Research Assistant Prof. at FIU University, Miami, USA
  • 2012-2014:   Associate Prof., Galgotias University, Grater Noida, UP
  • 2015-        :    Associate Prof. at KRMU University
Biography

She had been at Florida International University (FIU), Miami, USA for five years. She joined FIU as Wallace H Coulter Foundation BME Young Inventor Award recipient for postdoctoral position and in this period, she had established research in nanotechnology for drug delivery applications. She had been later in 2011 promoted to Research Assistant professor in the same department. She had also been awarded with the NIH R15 grant in 2013.

Furthermore, during her time at FIU, she had authored several peer-reviewed articles conference proceedings, and book chapter. During the past years she had prepared novel cancer therapies which can simultaneously carry imaging/hyperthermia and anticancer drugs together to the tumor target site. This delivery system may provide a more efficient and less harmful solution to overcome the limitations found in conventional chemotherapy. She had learned a great deal during her time at FIU.

During her stay at Univ de Paris-Sud, France, her research project was focused on the development of a blood substitute, based on a nanoparticle with hemoglobin. Long circulating nanoparticles were prepared and modified by chemical reaction. Modified particles were prepared in order to increase the hemoglobin binding and were further used them as an artificial oxygen carrier

In 2007, she received Young Scientist Project from Department of Science and Technology (SERC Fast Track Proposals for Young Scientists Scheme), Government of India, March 2007, entitled “Development of novel nanoparticle and nanoparticlate based targeted drug delivery systems and artificial oxygen carrier systems.”

In 2012, after joining at Galgotias University, she taught across the range of programmes and involved delivery of the course. She actively participated in subject design, recent development, and management and reviews the curriculum to improve the effectiveness of teaching for best practice and command of the field. On the research prospects, she wrote and helped other researchers in writing grant proposals. She also took part in development opportunities to improve research and supervision skills.

She enjoys and encourages creative interdisciplinary work. She feels very fortunate to closely work with a very large number of clinicians, doctors and biomedical engineers from various disciplines. She is very passionate about contributing for creation of high quality higher educational programs.

Interest Area(s)

  1. Nanotechnology for cancer applications
  2. Sustained Drug delivery systems.
  3. Trigger release of drugs using by different means
Research

  • Nanotechnology for cancer applications
  • Sustained Drug delivery systems.
  • Trigger release of drugs using by different means
  • Professional Projects / Professional Achievements

    A. Research Support 

    Research Support

    (Manchanda-PI) Transferred to (Dr. McGoron -Co-PI) 2013-2015

    Source: National Institute of Health (R15)

    Title: Novel Polymeric nanoparticles for drug delivery applications

    The goal of this study to develop biodegradable polymer nanoparticles loaded with an imaging agent and near infrared light triggered release mechanism of chemotherapeutic drugs.

    Completed Research Projects and Support

    Past Support

    (McGoron) 11/01/2007 - 5/30/2010

    Source: FIU Foundation

    Title: Young Inventor Award

    The goal of this project is to generate liposomes and polymer micro- and nano-particles for drug delivery applications. Most recently we developed new particles for breast cancer and liver cancer research. My role is to optimize the encapsulation of doxorubicin and indocyanine green into PLGA nanoparticles and characterize the particles using SEM, TEM and DLS.

    B. Awards and fellowships

    • Awarded NIH R15 grant entitled “Novel Polymeric nanoparticles for drug delivery applications”. 2013.
    • Young Scientist Project from Department of Science and Technology (SERC Fast Track Proposals for Young Scientists Scheme), Government of India, March 2007, entitled “Development of novel nanoparticle and nanoparticlate based targeted drug delivery systems and artificial oxygen carrier systems.”
    • Wallace H Coulter Foundation, BME Young Inventor Award. 2007. Biomedical Engineering Department, Florida International University. 
    Publications

    1. Nanoparticles coated with polysaccharides coupled to hemoglobin: an artificial oxygen carrier. E.P.F. workshop on "Polymer nanoparticles in life science" Paris, May 24-25 2004. Universite' Pierre & Marie Curie.
    2. Hemoglobin Loaded on a new generation of nanoparticles: artificial oxygen carrier. Journée du 16 mars 2006 in Lyon.
    3. Alicia Fernandez-Fernandez , Romila Manchanda , Tinjguin Lei, Deny Carvajal , Anthony J. McGoron. Novel IR820-PEG-diamine nanoparticles for combined imaging and therapy: in vitro studies. BMES 2010. Poster presentation
    4. Targeted delivery of indocyanine green and doxorubicin simultaneously loaded poly(lactide-co-glycolide) (PLGA) nanoparticles: An in vitro study. An AACR Special Conference on Nano in Cancer. January 12-15, 2011, Miami, FL.
    5. A Novel dual agent loaded PLGA nanoparticles for simultaneous delivery of chemotherapy and Hyperthermia. Biomedical Engineenering Society. (2010).
    6. Novel IR820-Pegdiamine nanoconjugates for combined Imaging and therapy: in vitro studies. Biomedical Engineering Society. (2010).
    7. Near-Infrared IR820-Chitosan Conjugate: In Vitro Studies. Biomedical Engineering Society.           ( 2011)
    8. Fernandez-Fernandez A, R. Manchanda, T. Lei, and A.J. McGoron. Preparation and
    1. Characterization of Covalent IR820-PEG Diamine Conjugates. BMES 2012 October24- 27 Atlanta GA.
    1. Tinjguin Lei, Romila Manchanda , YC Huang, Anthony J McGoron. Thermal and pH Sensitive Multifunctional Polymer nanoparticles for Cancer Therapy. BMES 2012. Atlanta
    2. Supriya Srinivasan, Romila Manchanda , Alicia Fernandez-Fernandez , Tinjguin Lei , Anthony J McGoron. Near-infrared IR820-chitosan conjugates: in vitro studies BMES 2011.
    3. Alicia Fernandez-Fernandez, Romila Manchanda, Supriya Srinivasan, Tinjguin Lei, Dany Carvajal, Anthony J. McGoron. IR820-chitosan conjugates for imaging and hyperthermia. SNM 2012 [J Nucl Med. 2012; 53 (Suppl. 1):1172].
    4. Tinjguin Lei, Alicia Fernandez-Fernandez, Yuan Tang, Dany Carvajal, Romila Manchanda, Sayed Z Kazmi, Anthony J. McGoron. A comparative study of IR-820 and indocyanine green (ICG). J Nucl Med. 2010; 51 (S2):225.
    5. Co-delivery of near-infrared (NIR) imaging and chemotherapeutic agent using polymeric nanoparticles.(2012) SNM 2012 Annual Meeting at the Miami BeachConvention Center, Miami, Florida, June 9-13, 2012
    6. Romila Manchanda, Alenjedro Amor, Seza Gulec, Anthony J McGoron, Chitosan Microspheres: Therapeutic Agent for Liver-directed Radiomicrosphere Therapy. (2012) SNM Annual Meeting, held June 9-13, Miami Beach Convention Center. 
    7. Romila Manchanda, Sunil K. Agarwal, P. Kumar, Ashwani K. Sharma, K.C. Gupta, Ramesh Chandra.   (2002).Preparation of high-loading polymer supports by polymerization reaction useful for oligonucleotide synthesis, Helv. Chim. Acta, 85, pp. 2754.
    8. Surendra Nimesh, Romila Manchanda, Rupesh Kumar, Preeti Chaudhary, Veena ,Yadav, Amit Saxena, Subho Mozumdar, Ramesh Chandra.(2006). Preparation, characterization and in vitro drug release studies of novel polymeric nanoparticles. International J. Pharmaceutics, 323, pp. 146-152.
    9. Yuan Tang, Tinjguin Lei, Romila Manchanda, Abhignyan Nagesetti, Alicia Fernandez- Fernandez, Supriya Srinivasan, Anthony J. McGoron. (2010), Simultaneous Delivery of Chemotherapeutic and Thermal-Optical Agents to Cancer Cells by a Polymeric (PLGA) Nanocarrier: an In Vitro Study. Pharmaceutical Research, 27, pp. 2242-2253.
    10. Romila Manchanda, Alicia. Fernanderz-Fernanderz, Abhignyan Nagesetti, Anthony J. McGoron. (2010).Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents. Colloids and Surfaces B: Biointerfaces, 75, pp. 260-267.
    11. Cédric Chauvierre, Romila Manchanda, Denis Labarre, Christine Vauthier, Michael C. Marden, Liliane Leclerc. (2010). Artificial oxygen carrier based on polysaccharides- poly(alkylcyanoacrylates) nanoparticle templates. Biomaterials, 31, pp. 6069-6074. 
    12. Romila Manchanda*, Surendra Nimesh. (2010). Controlled Size Chitosan Nanoparticles as an efficient, Biocompatible Oligonucleotides delivery System. Journal of Applied polymer science. 118(4):2071-2077.
    13. Tingjun Lei, Supriya Srinivasan, Yuan Tang, Romila Manchanda, Abhignyan Nagesetti, Alicia Fernandez-Fernandez, Anthony J. McGoron. Comparing Cellular Uptake and Cytotoxicity of Targeted Drug Carriers in Cancer Cell Lines with Different Drug Resistance Mechanisms. (2011) Nanomedicine: nanotechnology, Biology and Medicine. 7(3) pp. 324-332..
    14. Alicia Fernandez-Fernandez, Romila Manchanda, Tingjun Lei, Denny A. Carvajal, Yuan Tang, Syed Zahid Raza Kazmi, Anthony J. McGoron. (2012). A Comparative Study of Optical and Heat Generation Properties of IR820 and Indocyanine Green.  Molecular Imaging. Apr 1; 11(2) pp. 99-113.
    15. Romila Manchanda, Alicia Fernandez-Fernandez, Denny A Carvajal, Tingjun Lei, Yuan Tang, Anthony J McGoron. (2012) Nanoplexes for Cell Imaging and Hyperthermia: In vitro Studies. J Biomed nanotechnol. 8(4) pp. 686-694.  
    16. Supriya Srinivasan, Romila Manchanda, Alicia Fernandez-Fernandez, Tinjguin Lei, Anthony J. McGoron. Near-infrared fluorescing IR820-chitosan conjugate for multifunctional cancer theranostic applications. (2013) J Photochem Photobiol B, Feb 5, 119 pp. 52-9
    17. Tingjun Lei, Alicia Fernandez-Fernandez, Romila Manchanda,Yen-Chih Huang, Anthony J. McGoron. Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating. (2014) Beilstein J. Nanotechnol, 5, pp. 313–322. 
    18. Tingjun Lei, Romila Manchanda, Alicia Fernandez- Fernandez, Yen-Chih Huang, Douglas Wright Anthony J. McGoron, Thermal and pH sensitive multifunctional polymer nanoparticles for cancer imaging and therapy. (2014).RSC Advances.4, pp. 17959-17968.
    19. Supriya Srinivasan, Romila Manchanda, Tingjun Lei, Abhignyan Nagesetti, Alicia Fernandez-Fernandez, Anthony J. McGoron, (2014), Targeted nanoparticles for simultaneous delivery of chemotherapeutic and hyperthermia agents- an in vitro study. ) J Photochem Photobiol.July 5, 136, pp. 81-90.  
    20. Alicia Fernandez-Fernandez, Romila Manchanda, Denny Carvajal, Tingjun Lei, Supriya Srinivasan, Anthony J. McGoron,(2014), Covalent IR820-PEG DiamineNanoconjugates for Theranostic Applications in Cancer, International Journal of Nanomedicine, 9, pp. 4631-4698
    21. Alejandro Amor Coarasa, Romila Manchanda, Seza Gulec, Anthony J. McGoron, Design and In-vitro Evaluation of Chitosan Microspheres as a Therapeutic  Agent for Liver-directed Radiomicrosphere Therapy (2015). Submitted to J of drug targeting.
    22. Romila Manchanda* and Anthony J. McGoron (2011), Drug Delivery through Multifunctional Polymeric Nanoparticle (Ed.), Nova Science Publishers Inc., US),  pp. 91-123. (Book Chapter)  
    23. Alicia Fernandez-Fernandez, Romila Manchanda, Anthony J McGoron (2011), Theranostic applications of nanomaterials in cancer: Image-guided therapy and multifunctional platforms. (Invited review).  Applied Biochemistry and Biotechnology. 165(7-8) pp. 1628-51.
    24. Symposium / Conference Proceedings/ Posters

    25. Romila Manchanda, Abhignyan Nagesetti, Alicia Fernandez-Fernandez, Anthony J. McGoron,  (2009), Development of a PLGA nanoparticlesth drug delivery system containing imaging/Hyperthermia/Chemotherapy agents, 25th Southern Biomedical Engineering Conference.
    26. Romila Manchanda, Tinjguin Lei, Yuan Tang, Alicia Fernandez‐Fernandez, Anthony J.  McGoron, (2010), Cellular Uptake and Cytotoxicity of a Novel ICG-DOX-PLGA Dual Agent Polymer Nanoparticle Delivery System, IFMBE Proceedings, 32, pp. 228-231.
    27. Romila Manchanda, Yin.C. Huang, Tinjguin Lei, Alicia Fernandez-Fernandez, Anthony J. McGoron, (2010), Novel biodegradable PGD Polymeric Nanoparticles: Preparation and Characterization. Biomedical Engineering Society Annual Meeting, Austin, TX. Oct 6-9.
    28. Tinjguin Lei, Supriya Srinivasan, Yuan Tang, Romila Manchanda, Alicia Fernandez‐Fernandez, Anthony J. Mcgoron. (2010). Targeted Delivery of Doxorubicin by PLGA Nanoparticles Increases Drug Uptake in Cancer Cell Lines. IFMBE Proceedings 32, p. 224-227.
    29. Tingjun Lei, Alicia Fernandez-Fernandez, Yuan Tang, Denny Carvajal, Romila Manchanda, Syed Zahid Raza Kazmi, Anthony J. McGoron. (2010). Comparative study of IR-820 and Indocyanine green (ICG). Society of Nuclear Medicine. (June 9).
    30. Alicia Fernandez-Fernandez, Romila Manchanda, Tinjguin Lei, Yuan Tang, Deny  Carvajal, Anthony J. McGoron. (2011). IR820-PEG-diamine nanocomplexes for image- guided hyperthermia. Nanoflorida September30-October1.Miami.FL.
    31. Supriya Srinivasan, Romila Manchanda, Alicia Fernendez-Fernendez, Tinjguin Lei, Anthony J McGoron,(2011). Near Infrared IR820-chitosan conjugate: Invitrostudies Biomedical Engeenering Society Annual meeting, October 12-15, Hartford, CT.
    32. Romila Manchanda, Tinjguin lei, Yin C Huang, Anthony J McGoron Near infrared imaging(NIR) loaded polymeric nanoparticles: invitro studies. Nanoflorida 2011: The 4th annual nanoscience Technology symposium, Miami FL.
    33. Alicia Fernandez-Fernandez, Romila Manchanda, Tinjguin Lei, Supriya Srinivasan, Anthony J. McGoron. (2012) Covalent IR820-PEG diamine nanoconjugate for imaging and hyperthermia. NanoFlorida. Tampa.
    34. Alicia Fernandez-Fernandez, Romila Manchanda , Tinjguin Lei , Supriya Srinivasan , Deny Carvajal , Anthony J McGoron, (2012). IR820 conjugates: theranostic  applications in cancer. NBCIC
    35. Alicia Fernandez-Fernandez ,Romila Manchanda , Tinjguin Lei, Supriya Srinivasan S, Anthony J. McGoron , (2012). IR820 conjugates for image-guided cancer therapy. World Congress of Medical Physics and Biomedical Engineering.
    36. Tinjguin Lei, Romila Manchanda, Anthony J McGoron. (2012) In vitro and In vivo studies of near-infrared imaging (NIR) loaded polymeric nanoparticles. Nanoflorida . Tampa.
    37. Tinjguin Lei, Romila Manchanda, Y-C Huang, Anthony J. McGoron, Simultaneous  delivery of chemotherapeutic and hyperthermia agents using polymeric nanoparticles: an in vitro study., World Congress 2012 Medical Physics and Biomedical Engineering, May 26-31, 2012, Beijing, China.
    38. Tinjguin Lei, Supriya Srinivasan, Yuan Tang, Romila Manchanda , Abhignyan Nagesetti, Alicia Fernandez-Fernandez, Anthony J. McGoron , Simultaneous delivery of chemotherapeutic and thermal-optical agents to cancer cells by a polymeric  nanocarrier: an in vitro study. BIT's 5th Annual World Congress of Cancer, May 18-20, 2012, Beijing, China
    39. Fernandez-Fernandez, A., R. Manchanda, D.A. Carvajal, T. Lei, and A.J. McGoron (2013)  Covalent IR820-PEG diamine conjugates: Characterization and in vivo biodistribution. Proceedings of SPIE BiOS.
    40. Tingjun Lei, Romila Manchanda, Yen-Chih Huang, Alicia Fernandez-Fernandez, Karina Bunetska, Andrew Milera, Azael Sarmiento,Anthony J. McGoron Near-infrared imaging loaded polymeric nanoparticles: In vitro and In vivo studies.2013 Proceedings of SPIE 2013.  February, San Francisco, California USA.
    41. Tingjun Lei, Anthony McGoron, Romila Manchanda, Alicia Fernandez-Fernandez,Yen-Chih Huang. Theranostic nanoparticles for imaging and therapy and cellular response after laser-induced heating. Accepted for oral presentation. SBEC2013. 2- 5 May, 2013 in Miami , USA
    42. Alicia Fernandez-Fernandez, RomilaManchanda, Denny A. Carvajal, Tingjun Lei, Anthony J McGoron. Multifunctional Covalent Nanoconjugate for Near-Infrared Imaging and Hyperthermia. Oral presentation. SBEC 2013, 2-5 May 2013 in Miami, USA.
    43. Anthony J. McGoron, Supriya Srinivasan, Tingjun Lei, Yuan Tang, and Romila Manchanda, (2013) Combined photothermal therapy and chemotherapy in cancer using HER-2 targeted PLGA nanoparticles, SPIE.